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Resveratrol: Promising Promotion in Cardioprotection against Coronary Heart Disease
Wednesday November 25, 2009
Resveratrol: Promising Promotion in Cardioprotection against Coronary Heart Disease
Jaime
Urdinola MD Medical Association Andes CS AK 9116 20 326 Bogotá DC Colombia - Tel 571/215 23 00 Ext 13 80
e-mail: jaimeurdinolamd@gmail.com blogger: http://www . urdinola.blogspot.com www.urdinolamenopausia2.blogspot.com
Symposium / Luncheon on Women's Health Menopause Medical Association and the Andes - Board Room - Wednesday November 25, 2009

The chemical structure of t-RESV is resveratrol (trans-3, 4 ',5-trihydroxystilbene).

Resveratrol is a phytoalexin (antibiotic compounds produced by plants in response to microbial growth and as inhibitors of food). Manufacturing


Resveratrol is used to make resveratrate from the root of Polygonum cuspidatum , a plant that comes from China. Once harvested the plant is sent to a laboratory in Belgium, where resveratrol is extracted through a process lasts 14 days. Resveratrol then passed through an advanced process of desalination to increase its potency. Thus begins the manipulation of resveratrol to make it resveratrate: three phosphate groups are added to each molecule in a process called phosphorylation. Once you become resveratrate, resveratrol becomes stable and compatible with the skin, allowing scientists to multiply by 5 its concentration to act on the longevity gene SIRT1.


Introduction In September 2009 at Harvard University in Boston, a conference on aging, with the participation of both the 120 Club (people trying to live up to that age) to the devotees of low-calorie diets. The heavy weight of the participants was Sirtris Pharmaceuticals. This company develops drugs that mimic resveratrol, a chemical found in some red wines. Resveratrol activates a class of proteins called sirtuins, of which the company derives its name. It is thought that activation of sirtuins help the body cope with hunger. If placed in mice and rats on a diet with 30% fewer calories, they can live up to 40% longer.

it seems that it managed to avoid the common degenerative diseases, thus obtaining not only a vida más larga, sino más tiempo con buena salud.

Sirtuínas
Las sirtuínas son una clase de enzimas, unas deacetilasas de histona, NAD-dependientes, que se
encuentran tanto en las células procariotas como en las eucariotas. Afectan al metabolismo celular, regulando la expresión de ciertos genes ( o epigenética ) dentro de las células eucariotas de vegetales y animales. El nombre proviene de S ilent mating type I nformation R egulation two , el gen responsable de la regulación celular en el interior de las levaduras, e -ina , terminación o conventional suffix for proteins.

The company Sirtris researchers believe that drugs that activate sirtuins, could mimic the process of making the body stronger and more resistant to disease and aging. It has been shown that in mice, the activators of sirtuins are effective against lung cancer or colon cancer, melanoma, lymphoma, Type 2 diabetes, cardiovascular disease and Alzheimer's. These drugs reduce inflammation, which suggests that humans could remedy problems such as irritable bowel syndrome or glaucoma.

Several clinical studies are in Phase 1 and 2 research. No
have shown that resveratrol increased lifespan in mice as it does in normal mice
obesity, as well as worms and flies.

Resveratrol red wine has long been associated with called "French Paradox
" reflecting the low incidence of heart disease (CHD) among the French despite the consumption of a diet high in saturated fat. It is a polyphenolic compound found in the skin of some red fruit such as grapes and plums, the red skin of peanuts and even peanut butter.

The interest stems from numerous epidemiological studies que demostraron una asociación entre el
consumo moderado de alcohol y la reducción en las cifras de la enfermedad coronaria, así como la reducción en la EC en bebedores especialmente de vino, en comparación con otro tipo de bebidas 1 . Frankel 2 demostró que los polifenoles del vino rojo inhibían la oxidación del colesterol LDL más que el antioxidante establecido, el α-tocoferol. Esto, por supuesto y como era de esperarse, llevó a los científicos a enfocarse en investigaciones que aclararan el efecto cardioprotector del vino rojo. Además, protege las células de la acumulación de lípidos and oxidative stress induced by hydrogen peroxide 3.

myocardial angiogenesis mediated by hypoxia / reoxygenation depends on a mechanism dependent on nuclear factor kB by increasing its DNA binding activity. Resveratrol synthase increased phosphorylated endothelial nitric oxide, by regulating the growth of endothelial cells. The Vascular Endothelial Growth Factor is a proangiogenic factor and a cardioprotective molecule that induces hemodynamic changes and microvascular permeability. You can see that the beneficial effects of resveratrol may have anti-ischemic basis multifactorial, increasing also the production of nitric oxide in endothelial cells 4 . Conclusions


This brief review demonstrates that resveratrol means great promise in the treatment of pathophysiological complications such as myocardial ischemia as well as hypercholesterolemia and diabetes by regulating several target molecules that protect the myocardium against injury disease, and to reduce ventricular remodeling. Thus treatment with resveratrol may be used for and development of therapeutic angiogenesis in patients with coronary artery disease
. References

1- Grønbaek M, Deis A, Sørensen TI, Becker U, Schnohr P, Jensen G. Mortality associated with moderate intakes of wine, beer, or spirits. BMJ. 1995; 310: 1165-9.
2- Frankel EN, Kanner J, German JB, Parks E, Kinsella JE. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet. 1993;341:454-7.
3- Dani C, Oliboni LS, Vanderlinde R, Pra D, Dias JF, Yoneama ML, Bonatto D, Salvador M, Henriques JA. Antioxidant activity and phenolic and mineral content of rose grape juice. J Med Food. 2009;12:188-92.
4- Penumathsa SV, Maulik N. Resveratrol: a promising agent in promoting cardioprotection against coronary heart disease. Can J Physiol Pharmacol. 2009, 87: 275-286.

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